I haven't jumped in (yet...) on that kickstarter that Reaper is doing for their Bones line, but boy is it tempting. Lovely miniatures, and really great pricig compared to the metal versions of those miniatures. The pricing on the add-ons is incredible too, with the dragon and the giants being a fraction of their metal figure cost.
OTOH, I did get rid of almost every last fantasy miniature I owned when I gave them to my friends' son. If I buy in on this kickstarter at the juicy Vampitre level and add-ons, it will represent pretty much the entirety of a fantasy collection for me, at least in terms of character miniatures ( I still have puh-lenty of toy buildings and what not).
For discussion's sake, let's pretend you're in a similar situation. You're going to jump in on that Vampire level, but can upgrade as much as you want with add-ons.
Whatever you end up with is going to be your entire universe/collection of people minis.
What would you do with it? What game or hack of a game would you use? How would you recycle minis for use between connected games? What's the setting info?
How would you design it to use the minis you have, as opposed to theoretical stuff outside of that collection?